Genetic architecture of exact same-sex sexual conclusion
Certainly one of pairs of men and women in the united kingdom Biobank relevant from the complete relative otherwise closer [because the recognized by genomic resemblance (14); n pairs = 106,979], significantly more closely relevant people were expected to be concordant during the terms of same-intercourse intimate decisions. Because of the modeling the fresh new telecommunications of relatedness certainly one of someone and the resemblance of the sexual behavior, we projected wide-sense heritability-brand new portion of adaptation in an attribute due to hereditary adaptation-on thirty two.4% [95% believe menstruation (CIs), 10.six in order to 54.3] (dining table S4). This guess try in line with prior estimates off faster twin knowledge (7).
To identify genetic variants [largely singlenucleotide polymorphisms (SNPs)] associated with same-sex sexual behavior, we performed a GWAS in the UK Biobank study (n = 408,995 individuals) (14). To increase power and generalizability of our results, we also performed a GWAS in the cohort from 23andMe using an equivalent variable (individuals who reported having had sex with “Other sex only” versus the other options on a seven-point scale regarding participants’ sexual partners) (n = 68,527 individuals, of which 12,933 reported same-sex sexual behavior) (table S3) (14). […]